melting

compute the melting temperature of nucleic acid duplex

Install

All systems
curl cmd.cat/melting.sh
Debian Debian
apt-get install melting
Ubuntu
apt-get install melting
image/svg+xml Kali Linux
apt-get install melting
Raspbian
apt-get install melting

melting

compute the melting temperature of nucleic acid duplex

This program computes, for a nucleic acid duplex, the enthalpy, the entropy and the melting temperature of the helix-coil transitions. Three types of hybridisation are possible: DNA/DNA, DNA/RNA, and RNA/RNA. The program first computes the hybridisation enthalpy and entropy from the elementary parameters of each Crick's pair by the nearest-neighbor method. Then the melting temperature is computed. The set of thermodynamic parameters can be easily changed, for instance following an experimental breakthrough.