probalign

multiple sequence alignment using partition function posterior probabilities

Install

All systems
curl cmd.cat/probalign.sh
Debian Debian
apt-get install probalign
Ubuntu
apt-get install probalign
image/svg+xml Kali Linux
apt-get install probalign
Windows (WSL2)
sudo apt-get update sudo apt-get install probalign
Raspbian
apt-get install probalign
Dockerfile
dockerfile.run/probalign

probalign

multiple sequence alignment using partition function posterior probabilities

Probalign uses partition function posterior probability estimates to compute maximum expected accuracy multiple sequence alignments. It performs statistically significantly better than the leading alignment programs Probcons v1.1, MAFFT v5.851, and MUSCLE v3.6 on BAliBASE 3.0, HOMSTRAD, and OXBENCH benchmarks. Probalign improvements are largest on datasets containing N/C terminal extensions and on datasets with long and heterogeneous length sequences. On heteregeneous length datasets containing repeats Probalign alignment accuracy is 10% and 15% higher than the other three methods when standard deviation of length is at least 300 and 400.